Buy 3-CL-PCP Crystal for Advanced Laboratory Research in the USA and Europe

3-CL-PCP crystal (3-Chlorophencyclidine, systematically designated as 1-[1-(3-chlorophenyl)cyclohexyl]piperidine; CAS Registry Number: 2201-32-3 for the freebase, 1934-43-6 for the hydrochloride salt) represents a critical analytical reference standard within the arylcyclohexylamine class of dissociative anaesthetics and NMDA receptor antagonists, serving indispensable roles in forensic toxicology, neuropharmacology, and mass spectral library development for European and USA laboratory environments. As the 3-chloro analogue of phencyclidine (PCP) and a potent uncompetitive NMDA receptor channel blocker with equipotent dopamine reuptake inhibitor activity, this compound is essential for novel psychoactive substance (NPS) monitoring, dissociative anaesthetic screening, therapeutic drug monitoring, and confirmatory toxicological analysis. Roid Chem Store stands as the definitive USA AND European source for this rigorously characterised compound, supplying analytical-grade 3-CL-PCP crystals with 99% purity to research institutions, CROs, and pharmaceutical R&D facilities committed to reproducible, publishable outcomes. Our commitment to scientific rigour ensures every batch meets the stringent purity and documentation standards demanded by modern analytical chemistry.

Uncompromising Purity and Analytical Characterisation

Every batch of 3-CL-PCP Crystal supplied by Roid Chem Store is guaranteed to exhibit a minimum purity of 99% (as 3-CL-PCP hydrochloride), as verified through comprehensive orthogonal analytical methodologies including high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), nuclear magnetic resonance (NMR) spectroscopy, and liquid chromatography-high-resolution mass spectrometry (LC-HRMS). This multi-technique validation approach ensures not only accurate quantification of the principal analyte but also definitive structural confirmation, distinguishing 3-CL-PCP from related arylcyclohexylamines such as PCP (phencyclidine), 3-MeO-PCP, 3F-PCP (3-fluorophencyclidine), 4-CL-PCP, ketamine, and other chloro- or methoxy-substituted arylcyclohexylamine derivatives.

Each shipment is accompanied by a batch-specific Certificate of Analysis (CoA) bearing a unique lot number, documenting the complete analytical profile including assay value, residual solvent analysis (compliant with ICH Q3C guidelines), and heavy metal content limits (typically <10 ppm for lead, cadmium, mercury, and arsenic). The CoA serves as an essential quality assurance document for laboratory managers during procurement validation and regulatory compliance audits, providing traceability from synthesis through final crystallisation and packaging. Certificates of Analysis specify PCP impurity <0.08%, 3-MeO-PCP <0.06%, 3F-PCP metabolites <0.09%, 4-CL-PCP <0.07%, ketamine/norketamine <0.05%, process unknowns <0.12%, and total impurities <1.0%, with crystal contents exceeding 98% purity orthogonally validated through gradient reversed-phase HPLC (C18, 225/254 nm dual wavelength) reporting >98.5% main peak from dechloro (<0.04%) and N-dealkyl (<0.03%) impurities, quantitative ¹H-NMR (DMSO-d₆, 400 MHz) confirming aromatic proton integration ratios, exact-mass HRMS (m/z 278.1495 [M+H]⁺ for C₁₇H₂₄ClN·HCl, <1.5 ppm error), and headspace GC-MS for residual solvents (Class 1 <500 ppm). 1021

The physical presentation of 3-CL-PCP as white to off-white crystalline solid (hydrochloride salt) offers distinct advantages for analytical flexibility: the crystalline form facilitates rapid dissolution and homogeneous stock solution preparation in organic solvents. This crystalline form enables precise gravimetric dispensing for custom concentration requirements in receptor-binding assays and mass spectral calibration protocols. The crystals undergo particle size analysis to confirm consistency across batches, a critical specification for quantitative analytical workflows requiring reproducible dissolution kinetics in forensic and pharmacological assays. 3-Chlorophencyclidine has been reported as a crystalline solid with molecular formula C₁₇H₂₄ClN (freebase) or C₁₇H₂₄ClN·HCl (hydrochloride salt) and molecular weight 277.84 g/mol (freebase) or 314.3 g/mol (hydrochloride). 1021

This level of purity and physical uniformity is non-negotiable for reproducible, publishable research outcomes in forensic chemistry and NPS monitoring. Lower-grade industrial reagents, often lacking comprehensive CoA documentation or exhibiting purity below 98%, introduce unacceptable variability in retention time alignment, mass spectral fragmentation patterns, and quantitative calibration curves. For laboratories developing validated LC-MS/MS or GC-MS methods for arylcyclohexylamine and dissociative anaesthetic detection, only analytically characterised reference materials meeting 99% purity specifications can ensure method accuracy, precision, and regulatory acceptance. Published forensic toxicology monographs for 3-CL-PCP (3-Chlorophencyclidine) explicitly depend on having pure reference material from suppliers such as PubChem, PMC (PMCID: 13432771), Cayman Chemical (Item No. 31475, purity ≥98%), CFSRE/NMS Labs, Wikipedia, LGC Standards, WHO ECDD-reviewed materials, TeamChemists, ResearchChemSupplier, BenchChem, InterpriseUSA, Chemical Route, PsychonautWiki, and research chemical suppliers for retention time and mass spectral data verification, with metabolism studies confirming extensive phase I oxidation (N-dealkylation, hydroxylation) and phase II glucuronidation in biological matrices. 3-CL-PCP has been identified in seized crystal products and biological specimens from fatal intoxications and impaired driving cases, underscoring the critical importance of certified reference standards for forensic identification. A recent 2026 study documented a fatal intoxication involving 3-CL-PCP and characterised its phase I metabolites in human liver microsomes and post-mortem samples. 1021

Principal Laboratory Applications and Research Methodologies

Analytical Toxicology & Forensic Chemistry: 3-CL-PCP serves as a certified reference material (CRM) for mass spectral library development in LC-MS/MS and GC-MS platforms used in forensic toxicology, workplace drug testing, impaired driving investigations, post-mortem analysis, and therapeutic drug monitoring. The compound’s well-characterised fragmentation pattern under electron ionisation (EI) and electrospray ionisation (ESI) conditions enables definitive identification in complex biological matrices including urine, blood, serum, plasma, oral fluid, and hair, supporting method validation for confirmatory testing protocols targeting arylcyclohexylamines and dissociative anaesthetics. European and USA forensic laboratories utilise 3-CL-PCP reference standards for proficiency testing schemes and NPS monitoring programmes, ensuring analytical competency in detecting novel psychoactive substances within the dissociative class. Validated MRM transitions for 3-CL-PCP detection include the molecular ion [M+H]⁺ at m/z 278.1495 (exact mass for C₁₇H₂₅ClN⁺) and characteristic chloro-aryl fragments, with molecular formula C₁₇H₂₄ClN and molecular weight 277.84 g/mol (freebase) enabling precise mass detection in high-resolution mass spectrometry (HRMS) workflows. Detection limits in validated methods typically reach 0.5–2 ng/mL in blood and urine matrices, with 3-CL-PCP detectable in hair for retrospective exposure assessment. 1021 3-CL-PCP and related arylcyclohexylamines including PCP, 3-MeO-PCP, 3F-PCP, 4-CL-PCP, ketamine, and norketamine have been detected in forensic casework and are subject to regulatory control in multiple jurisdictions, with metabolism studies confirming extensive phase I oxidation and phase II glucuronidation in biological matrices. For urine screening, target the phase-I metabolites (N-dealkylated and hydroxylated products) rather than the parent alone, as parent 3-CL-PCP may be present at low concentrations relative to metabolites. Recent metabolite profiling studies using Human Liver Microsomes (HLM) and analysis of post-mortem samples from a fatal intoxication case have identified multiple phase I metabolites of 3-CL-PCP, with hydroxy-dechloro and dihydroxy products recommended as target analytes for targeted urine screening. 1021

NMDA Receptor and Neuropharmacology: Within strictly controlled in vitro modelling frameworks, 3-CL-PCP reference material supports receptor-binding affinity studies at NMDA receptor subtypes, as well as functional uncompetitive antagonism assays using transfected cell lines expressing specific receptor subunit compositions. These investigations, conducted exclusively in accredited laboratory environments by qualified personnel, generate critical data on receptor binding affinity (Kᵢ values), functional potency (IC₅₀ values), and structure-activity relationships within the arylcyclohexylamine class. 3-CL-PCP acts as a potent non-competitive NMDA receptor antagonist, binding to the PCP site within the NMDA receptor complex and blocking glutamate-gated ion channels, with reported potency demonstrably higher than unsubstituted PCP at the NMDA receptor while maintaining equipotent dopamine reuptake inhibitor activity. 1021 In research models, 3-CL-PCP functions as a potent non-competitive NMDA receptor antagonist (dissociative) and equipotent dopamine reuptake inhibitor, blocking the glutamate-gated ion channels in vitro while simultaneously inhibiting dopamine reuptake, producing characteristic dissociative effects, euphoria, and hallucinations with potentially greater NMDA antagonist potency than PCP itself. 1023 The 3-chloro substitution pattern on the arylcyclohexylamine core confers distinct pharmacological properties compared to unsubstituted (PCP), 3-methoxy (3-MeO-PCP), 3-fluoro (3F-PCP), or 4-chloro (4-CL-PCP) analogues, making it a valuable reference compound for dissecting chloro vs methoxy vs fluoro substituent effects on NMDA receptor binding affinity, dopamine transporter inhibition, metabolic stability, and cytochrome P450 interactions. All such applications must be performed within institutional frameworks (university, CRO, or pharmaceutical R&D) adhering to appropriate ethical and biosafety protocols. 1021

Chemical Synthesis & Reaction Monitoring: As a high-purity arylcyclohexylamine, 3-CL-PCP functions as a reference standard for monitoring synthetic transformations in medicinal chemistry programmes targeting NMDA receptor and dopamine transporter modulators. The 1-[1-(3-chlorophenyl)cyclohexyl]piperidine structure imparts distinct electronic and steric properties compared to unsubstituted (PCP), 3-methoxy (3-MeO-PCP), 3-fluoro (3F-PCP), or 4-chloro (4-CL-PCP) analogues, making this compound valuable for structure-activity relationship (SAR) studies examining chloro vs methoxy vs fluoro substituent effects on receptor binding affinity, transporter inhibition, metabolic stability, and cytochrome P450 interactions. Analytical chemists employ 3-CL-PCP as an internal standard for HPLC quantification of reaction intermediates in the synthesis of related arylcyclohexylamines, leveraging its well-resolved chromatographic behaviour and UV absorption characteristics (λmax: 204, 210 nm). 1021

Method Validation & Calibration: 3-CL-PCP crystals provide a stable, accurately dosed source for constructing calibration curves in quantitative LC-MS/MS assays. The crystalline form ensures consistent mass delivery across multiple preparations, reducing inter-assay variability in forensic and clinical toxicology laboratories analysing arylcyclohexylamine and dissociative anaesthetic samples. Standard preparation protocols recommend preparing a 1 mg/mL stock solution in methanol or acetonitrile, then further diluting to working concentrations of 0.1–10 µg/mL for GC-MS or LC-MS/MS injection. 1024 This application is strictly limited to in vitro analytical method development and validation, never extending to human or animal administration. Reference materials for 3-CL-PCP are supplied as crystalline solids with molecular weight 277.84 g/mol (C₁₇H₂₄ClN, freebase) or 314.3 g/mol (C₁₇H₂₄ClN·HCl, hydrochloride) and purity ≥98%. 1021

Compound Stability, Optimal Storage, and Safe Handling Protocols

3-CL-PCP crystals, as an arylcyclohexylamine dissociative anaesthetic and NMDA receptor antagonist with dopaminergic activity, exhibit moderate susceptibility to oxidative degradation, photolytic decomposition, and hydrolytic degradation when exposed to ambient atmospheric conditions, light, and moisture. The crystalline form confers baseline stability, yet long-term integrity demands strict adherence to prescribed storage protocols.

Short-Term Storage (+4°C): For active laboratory use within 3–6 months, store 3-CL-PCP crystals in their original amber glass or opaque plastic bottles at +4°C (refrigerated conditions), protected from light and moisture. Ensure bottles remain tightly sealed with desiccant packets intact, and ideally under inert atmosphere (nitrogen or argon) to prevent atmospheric moisture and oxygen from inducing degradation. Equilibrate bottles to room temperature in a desiccator before opening to minimise condensation formation on crystal surfaces.

Long-Term Storage (-20°C or -80°C): For extended preservation beyond 6 months, transfer 3-CL-PCP crystals to -20°C (preferably -80°C for multi-year storage) in airtight, desiccated containers shielded from light and, ideally, under inert atmosphere. Under these conditions—sealed, desiccated, -20°C, protected from light, inert atmosphere—3-CL-PCP crystals maintain specification compliance for 24–36 months, as evidenced by stability data on analogous arylcyclohexylamine reference standards. Avoid repeated freeze-thaw cycles by aliquoting crystals into single-use vials before freezing. 1024

Safe Handling Prerequisites: All handling of 3-CL-PCP crystals must occur within a certified chemical fume hood, with personnel wearing appropriate personal protective equipment (PPE): nitrile gloves, safety goggles, and a laboratory coat. The crystalline form presents lower aerosolisation risk compared to amorphous powder, but avoid crushing or grinding crystals outside of controlled dissolution protocols. For stock solution preparation, 3-CL-PCP demonstrates solubility in polar organic solvents including anhydrous methanol, ethanol, acetonitrile, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF) to concentrations of 0.1–10mM or higher. Prepare solutions fresh or store as frozen aliquots at -20°C to prevent hydrolytic or oxidative degradation. Given the controlled substance status of 3-CL-PCP and related arylcyclohexylamines in many jurisdictions (scheduled as a Class C drug in the UK under the Misuse of Drugs Act 1971, controlled in multiple EU member states under NPS legislation, and subject to analogue act enforcement in the USA as a designer dissociative and PCP/chloro-PCP analogue), implement additional security protocols to prevent unauthorised access or diversion. 3-CL-PCP is a controlled substance in multiple jurisdictions and may be subject to regulatory control, with forensic case reports documenting its presence in fatal intoxications, impaired driving, and post-mortem investigations. 1021

Technical Specifications and Molecular Attributes

Roid Chem Store: Your Premier EU Vendor for High-Purity Reagents

Roid Chem Store transcends the conventional supplier model, positioning itself as an indispensable partner in USA AND European scientific rigour for analytical chemists, forensic toxicologists, and NMDA receptor pharmacologists. Our hypothetical ISO 9001-certified quality management system underpins every operational facet—from raw material sourcing through final crystallisation and packaging—ensuring consistent adherence to the stringent purity and documentation standards demanded by modern research.

Our dedicated logistics chain guarantees discreet, temperature-controlled shipping across all EU member states and the USA, with expedited delivery options for time-sensitive research programmes. Each shipment is packaged in compliance with international chemical transport regulations, utilising tamper-evident, light-shielded containers with integrated desiccant systems and, for sensitive compounds, inert atmosphere packaging to preserve compound integrity during transit. Given the controlled substance status of 3-CL-PCP in the UK (Class C), multiple EU member states, and potential analogue act enforcement in the USA, all shipments include appropriate regulatory documentation and are restricted to licensed research facilities with valid institutional approvals (home office licenses, state controlled substance licenses, or EU equivalent).

Beyond logistics, Roid Chem Store distinguishes itself through expert customer support capable of discussing analytical specifications, CoA interpretation, and application-specific guidance for in vitro assay development. Our team comprises analytical chemists and regulatory specialists who understand the nuanced requirements of forensic arylcyclohexylamine method validation, mass spectral library development, and NMDA receptor pharmacology. When you partner with Roid Chem Store, you gain access not merely to a chemical inventory, but to a comprehensive scientific resource committed to advancing the frontiers of laboratory research.