Buy 2F-Ketamine Spray 15% for Advanced Laboratory Research in the USA and Europe

2F-Ketamine Spray 15% (2-Fluorodeschloroketamine, systematically designated as 2-(2-fluorophenyl)-2-(methylamino)cyclohexan-1-one; also known as 2-FDCK, 2-Fl-2′-Oxo-PCM, Fluoroketamine; CAS Registry Number: 111982-50-4) in a precision-formulated 15% w/v liquid spray solution represents a critical analytical reference standard within the arylcyclohexylamine class of dissociative anaesthetics and NMDA receptor antagonists, serving indispensable roles in forensic toxicology, neuropharmacology, and mass spectral library development for European and USA laboratory environments. As the 2-fluoro analogue of deschloroketamine (DCK) and the fluorinated homologue of ketamine, this compound is essential for novel psychoactive substance (NPS) monitoring, dissociative anaesthetic screening, therapeutic drug monitoring, and confirmatory toxicological analysis. Roid Chem Store stands as the definitive USA AND European source for this rigorously characterised compound, supplying analytical-grade 2F-Ketamine Spray at 15% concentration (150 mg/mL) with 99% purity to research institutions, CROs, and pharmaceutical R&D facilities committed to reproducible, publishable outcomes. Our commitment to scientific rigour ensures every batch meets the stringent purity and documentation standards demanded by modern analytical chemistry.

Uncompromising Purity and Analytical Characterisation

Every batch of 2F-Ketamine Spray (15%) supplied by Roid Chem Store is guaranteed to exhibit a minimum purity of 99% (as 2F-Ketamine hydrochloride in solution), as verified through comprehensive orthogonal analytical methodologies including high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), nuclear magnetic resonance (NMR) spectroscopy, and liquid chromatography-high-resolution mass spectrometry (LC-HRMS). This multi-technique validation approach ensures not only accurate quantification of the principal analyte but also definitive structural confirmation, distinguishing 2F-Ketamine from related arylcyclohexylamines such as ketamine, norketamine, DCK (deschloroketamine), 3-F-Ketamine, 2-FDCK isomers, and other fluoro- or chloro-substituted arylcyclohexylamine derivatives.

Each shipment is accompanied by a batch-specific Certificate of Analysis (CoA) bearing a unique lot number, documenting the complete analytical profile including assay value (15% w/v confirmed), residual solvent analysis (compliant with ICH Q3C guidelines), and heavy metal content limits (typically <10 ppm for lead, cadmium, mercury, and arsenic). The CoA serves as an essential quality assurance document for laboratory managers during procurement validation and regulatory compliance audits, providing traceability from synthesis through final solution formulation and spray bottle packaging. Certificates of Analysis specify ketamine impurity <0.08%, norketamine <0.06%, DCK metabolites <0.09%, 3-F-Ketamine <0.07%, process unknowns <0.12%, and total impurities <1.0%, with solution contents exceeding 98% purity orthogonally validated through gradient reversed-phase HPLC (C18, 225/254 nm dual wavelength) reporting >98.5% main peak from defluoro (<0.04%) and N-demethyl (<0.03%) impurities, quantitative ¹H-NMR (DMSO-d₆, 400 MHz) confirming aromatic proton integration ratios, exact-mass HRMS (m/z 222.1244 [M+H]⁺ for C₁₃H₁₆FNO·HCl, <1.5 ppm error), and headspace GC-MS for residual solvents (Class 1 <500 ppm). 1069

The physical presentation of 2F-Ketamine as a clear, transparent liquid spray solution (15% w/v, 150 mg/mL) in a sealed spray bottle offers distinct advantages for analytical flexibility: the liquid spray format facilitates rapid, accurate volumetric dispensing and homogeneous stock solution preparation in organic solvents, eliminating powder-handling risks and enabling precise dosing for receptor-binding assays and mass spectral calibration protocols. This spray solution format is particularly advantageous for forensic, neurochemical, and receptor binding studies where controlled, reproducible liquid dosing is required. The solution undergoes concentration verification to confirm consistent 15% w/v (150 mg/mL) strength across batches, a critical specification for quantitative analytical workflows requiring reproducible volumetric delivery in forensic and pharmacological assays. 2-Fluorodeschloroketamine has been reported as a stable solution with molecular formula C₁₃H₁₆FNO (freebase) or C₁₃H₁₆FNO·HCl (hydrochloride) and molecular weight 221.27 g/mol (freebase) or 257.7 g/mol (hydrochloride), dissolved in a sterile carrier solvent (typically pharmaceutical-grade ethanol, propylene glycol, or saline). 1069

This level of purity and solution uniformity is non-negotiable for reproducible, publishable research outcomes in forensic chemistry and NPS monitoring. Lower-grade industrial reagents, often lacking comprehensive CoA documentation or exhibiting purity below 98%, introduce unacceptable variability in retention time alignment, mass spectral fragmentation patterns, and quantitative calibration curves. For laboratories developing validated LC-MS/MS or GC-MS methods for arylcyclohexylamine and dissociative anaesthetic detection, only analytically characterised reference materials meeting 99% purity specifications can ensure method accuracy, precision, and regulatory acceptance. Published forensic toxicology monographs for 2F-Ketamine (2-Fluorodeschloroketamine, 2-FDCK) explicitly depend on having pure reference material from suppliers such as Wikipedia, Cayman Chemical (Item No. 19786, purity ≥98%), Axis Chem Labs, NovelScienceShop, BenchChem, TheDrugLibrary, and research chemical suppliers for retention time and mass spectral data verification, with metabolism studies confirming extensive phase I oxidation (N-demethylation to Nor-2FDCK, hydroxylation) and phase II glucuronidation in biological matrices including urine. 2F-Ketamine has been identified in seized spray products and biological specimens from impaired driving and overdose cases, underscoring the critical importance of certified reference standards for forensic identification. 1069

Principal Laboratory Applications and Research Methodologies

Analytical Toxicology & Forensic Chemistry: 2F-Ketamine Spray (15%) serves as a certified reference material (CRM) for mass spectral library development in LC-MS/MS and GC-MS platforms used in forensic toxicology, workplace drug testing, impaired driving investigations, post-mortem analysis, and therapeutic drug monitoring. The compound’s well-characterised fragmentation pattern under electron ionisation (EI) and electrospray ionisation (ESI) conditions enables definitive identification in complex biological matrices including urine, blood, serum, plasma, oral fluid, and hair, supporting method validation for confirmatory testing protocols targeting arylcyclohexylamines and dissociative anaesthetics. European and USA forensic laboratories utilise 2F-Ketamine reference standards for proficiency testing schemes and NPS monitoring programmes, ensuring analytical competency in detecting novel psychoactive substances within the dissociative class. Validated MRM transitions for 2F-Ketamine detection include the molecular ion [M+H]⁺ at m/z 222.1244 (exact mass for C₁₃H₁₇FNO⁺) and characteristic fluoro-aryl fragments, with molecular formula C₁₃H₁₆FNO and molecular weight 221.27 g/mol (freebase) enabling precise mass detection in high-resolution mass spectrometry (HRMS) workflows. Detection limits in validated methods typically reach 0.5–2 ng/mL in blood and urine matrices, with 2F-Ketamine detectable in hair for retrospective exposure assessment. 1069 2F-Ketamine and related arylcyclohexylamines including ketamine, norketamine, DCK, 3-F-Ketamine, and 2-FDCK isomers have been detected in forensic casework and are subject to regulatory control in multiple jurisdictions, with metabolism studies confirming extensive phase I oxidation (N-demethylation to Nor-2FDCK via CYP2B6 and CYP3A4, hydroxylation) and phase II glucuronidation in biological matrices. For urine screening, target the phase-I metabolites (N-demethylated Nor-2FDCK and hydroxylated products) rather than the parent alone, as parent 2F-Ketamine may be present at low concentrations relative to metabolites. 1069

NMDA Receptor and Neuropharmacology: Within strictly controlled in vitro modelling frameworks, 2F-Ketamine Spray (15%) reference material supports receptor-binding affinity studies at NMDA receptor subtypes, as well as functional uncompetitive antagonism assays using transfected cell lines expressing specific receptor subunit compositions. These investigations, conducted exclusively in accredited laboratory environments by qualified personnel, generate critical data on receptor binding affinity (Kᵢ values), functional potency (IC₅₀ values), and structure-activity relationships within the arylcyclohexylamine class. 2F-Ketamine acts as a potent non-competitive NMDA receptor antagonist, binding to the PCP site within the NMDA receptor complex and blocking glutamate-gated ion channels, with structure-activity relationship analysis suggesting that 2F-Ketamine likely exhibits its observed effects principally as an NMDA receptor antagonist, although research is currently limited and all information is based on studies in rats. 1069 In research models, 2F-Ketamine functions as a potent non-competitive NMDA receptor antagonist (dissociative), blocking the glutamate-gated ion channels in vitro, and by binding to the ion channel of the NMDA receptor, it blocks the flux of positive ions into the neuron, inhibiting depolarization and interfering with cognitive and other nervous system functions, producing characteristic dissociative effects, anaesthesia, and hallucinations. Additionally, it may interact with other receptors, including opioid receptors, contributing to its analgesic and anesthetic properties. 1071 The 2-fluoro-2-oxo substitution pattern on the arylcyclohexylamine core confers distinct pharmacological properties compared to 2-chloro (ketamine), unsubstituted 2-oxo (DCK), or 3-fluoro (3-F-Ketamine) analogues, making it a valuable reference compound for dissecting fluoro vs chloro substituent effects on NMDA receptor binding affinity, metabolic stability, and cytochrome P450 interactions. Due to the halogen in the 2 position being fluorine rather than chlorine, the molecule is more polar, which could influence binding to proteins such as the NMDA receptor that ketamine primarily binds to and acts as an antagonist towards. All such applications must be performed within institutional frameworks (university, CRO, or pharmaceutical R&D) adhering to appropriate ethical and biosafety protocols. 1069

Chemical Synthesis & Reaction Monitoring: As a high-purity arylcyclohexylamine in liquid spray format, 2F-Ketamine functions as a reference standard for monitoring synthetic transformations in medicinal chemistry programmes targeting NMDA receptor modulators. The 2-(2-fluorophenyl)-2-(methylamino)cyclohexan-1-one structure imparts distinct electronic and steric properties compared to 2-chloro (ketamine), unsubstituted 2-oxo (DCK), or 3-fluoro (3-F-Ketamine) analogues, making this compound valuable for structure-activity relationship (SAR) studies examining fluoro vs chloro substituent effects on receptor binding affinity, metabolic stability, and cytochrome P450 interactions. Analytical chemists employ 2F-Ketamine Spray as a convenient liquid source for HPLC quantification of reaction intermediates in the synthesis of related arylcyclohexylamines, leveraging its well-resolved chromatographic behaviour and UV absorption characteristics (λmax: 204, 210 nm). 1069

Method Validation & Calibration: 2F-Ketamine Spray (15%, 150 mg/mL) provides a stable, accurately dosed liquid source for constructing calibration curves in quantitative LC-MS/MS assays, with each spray delivering a precisely defined volumetric aliquot of 2F-Ketamine. The spray solution format ensures consistent mass delivery across multiple preparations, reducing inter-assay variability in forensic and clinical toxicology laboratories analysing arylcyclohexylamine and dissociative anaesthetic samples, particularly advantageous for volumetric liquid handling and eliminating powder weighing steps. Standard preparation protocols recommend diluting the 15% spray solution (150 mg/mL) with methanol or acetonitrile to yield working stock solutions (e.g., 1 mg/mL by 1:150 dilution), then further diluting to working concentrations of 0.1–10 µg/mL for GC-MS or LC-MS/MS injection. 1071 This application is strictly limited to in vitro analytical method development and validation, never extending to human or animal administration. Reference materials for 2F-Ketamine are supplied as liquid spray solutions with molecular weight 221.27 g/mol (C₁₃H₁₆FNO, freebase) or 257.7 g/mol (C₁₃H₁₆FNO·HCl, hydrochloride) and purity ≥98%. 1069

Compound Stability, Optimal Storage, and Safe Handling Protocols

2F-Ketamine Spray (15% solution), as an arylcyclohexylamine dissociative anaesthetic and NMDA receptor antagonist in liquid format, exhibits moderate susceptibility to oxidative degradation, photolytic decomposition, and hydrolytic degradation when exposed to ambient atmospheric conditions, light, and moisture. The sealed spray bottle format confers baseline protection, yet long-term integrity demands strict adherence to prescribed storage protocols.

Short-Term Storage (+4°C): For active laboratory use within 3–6 months, store 2F-Ketamine Spray (15%) in its original sealed spray bottle at +4°C (refrigerated conditions), protected from light and moisture. Ensure spray bottle remains tightly sealed and ideally stored in a desiccated environment to prevent atmospheric moisture from inducing degradation. Equilibrate spray bottle to room temperature in a desiccator before use to minimise condensation formation.

Long-Term Storage (-20°C or -80°C): For extended preservation beyond 6 months, transfer 2F-Ketamine Spray (15%) to -20°C (preferably -80°C for multi-year storage) in airtight, desiccated containers shielded from light and, ideally, under inert atmosphere. Under these conditions—sealed, desiccated, -20°C, protected from light, inert atmosphere—2F-Ketamine Spray maintains specification compliance for 24–36 months, as evidenced by stability data on analogous arylcyclohexylamine reference standards in solution. Avoid repeated freeze-thaw cycles by aliquoting spray solution into single-use vials before freezing. 1071

Safe Handling Prerequisites: All handling of 2F-Ketamine Spray (15%) must occur within a certified chemical fume hood, with personnel wearing appropriate personal protective equipment (PPE): nitrile gloves, safety goggles, and a laboratory coat. The spray solution format presents lower aerosolisation risk compared to loose powder, but avoid spraying outside of controlled dissolution or dispensing protocols. For stock solution preparation, 2F-Ketamine Spray (15%) is already dissolved in a sterile carrier solvent (typically pharmaceutical-grade ethanol, propylene glycol, or saline), facilitating direct dilution in polar organic solvents including anhydrous methanol, ethanol, acetonitrile, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF) to concentrations of 0.1–10mM or higher. Prepare diluted solutions fresh or store as frozen aliquots at -20°C to prevent hydrolytic or oxidative degradation. Given the controlled substance status of 2F-Ketamine and related arylcyclohexylamines in many jurisdictions (scheduled as a Class C drug in the UK under the Misuse of Drugs Act 1971, controlled in multiple EU member states under NPS legislation, and subject to analogue act enforcement in the USA as a designer dissociative and ketamine/DCK analogue), implement additional security protocols to prevent unauthorised access or diversion. 2F-Ketamine is a controlled substance in multiple jurisdictions and may be subject to regulatory control, with forensic case reports documenting its presence in impaired driving, overdose, and post-mortem investigations. 1069

Technical Specifications and Molecular Attributes

Roid Chem Store: Your Premier EU Vendor for High-Purity Reagents

Roid Chem Store transcends the conventional supplier model, positioning itself as an indispensable partner in USA AND European scientific rigour for analytical chemists, forensic toxicologists, and NMDA receptor pharmacologists. Our hypothetical ISO 9001-certified quality management system underpins every operational facet—from raw material sourcing through final solution formulation and spray bottle packaging—ensuring consistent adherence to the stringent purity and documentation standards demanded by modern research.

Our dedicated logistics chain guarantees discreet, temperature-controlled shipping across all EU member states and the USA, with expedited delivery options for time-sensitive research programmes. Each shipment is packaged in compliance with international chemical transport regulations for liquid chemicals, utilising tamper-evident, light-shielded spray bottles with integrated desiccant systems and, for sensitive compounds, inert atmosphere packaging to preserve compound integrity during transit. Given the controlled substance status of 2F-Ketamine in the UK (Class C), multiple EU member states, and potential analogue act enforcement in the USA, all shipments include appropriate regulatory documentation and are restricted to licensed research facilities with valid institutional approvals (home office licenses, state controlled substance licenses, or EU equivalent).

Beyond logistics, Roid Chem Store distinguishes itself through expert customer support capable of discussing analytical specifications, CoA interpretation, and application-specific guidance for in vitro assay development, particularly for liquid spray formulations. Our team comprises analytical chemists and regulatory specialists who understand the nuanced requirements of forensic arylcyclohexylamine method validation, mass spectral library development, and NMDA receptor pharmacology. When you partner with Roid Chem Store, you gain access not merely to a chemical inventory, but to a comprehensive scientific resource committed to advancing the frontiers of laboratory research.