Buy 2C-B-FLY Pellets 10mg for Advanced Laboratory Research in the USA and Europe

2C-B-FLY pellets 10mg (8-Bromo-2,3,6,7-tetrahydrofuro[2,3-f]benzofuran-4-yl)ethanamine, systematically designated as 2-(8-bromo-2,3,6,7-tetrahydrofuro[2,3-f]benzofuran-4-yl)ethanamine; also known as 2C-B-Fly, 2C-B-Butterfly, 8-bromo-FLY, BDF; CAS Registry Number: 178557-21-6 for the freebase, 178557-21-6 for the hydrochloride salt) represent a critical analytical reference standard within the phenethylamine and benzodihydrodifuran (FLY) class of novel psychoactive substances (NPS), serving indispensable roles in forensic toxicology, serotonin receptor pharmacology, and mass spectral library development for European and USA laboratory environments. As a conformationally restricted, ring-fused analogue of 2C-B (4-bromo-2,5-dimethoxyphenethylamine) where the 2,5-dimethoxy groups are bridged by a dihydrodifuran ring system, this compound is essential for novel psychoactive substance (NPS) monitoring, psychedelic screening, therapeutic drug monitoring, and confirmatory toxicological analysis. Roid Chem Store stands as the definitive USA AND European source for this rigorously characterised compound, supplying analytical-grade 2C-B-FLY pellets at 10mg strength with 99% purity to research institutions, CROs, and pharmaceutical R&D facilities committed to reproducible, publishable outcomes. Our commitment to scientific rigour ensures every batch meets the stringent purity and documentation standards demanded by modern analytical chemistry.

Uncompromising Purity and Analytical Characterisation

Every batch of 2C-B-FLY Pellets (10mg) supplied by Roid Chem Store is guaranteed to exhibit a minimum purity of 99% (as 2C-B-FLY hydrochloride), as verified through comprehensive orthogonal analytical methodologies including high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), nuclear magnetic resonance (NMR) spectroscopy, and liquid chromatography-high-resolution mass spectrometry (LC-HRMS). This multi-technique validation approach ensures not only accurate quantification of the principal analyte but also definitive structural confirmation, distinguishing 2C-B-FLY from related phenethylamines and FLY analogues such as 2C-B, Bromo-DragonFLY (DOB-DFLY), 2C-B-Butterfly, 2C-I-FLY, 2C-T-FLY, DOB, DOI, and other bromo- or methoxy-substituted phenethylamine derivatives.

Each shipment is accompanied by a batch-specific Certificate of Analysis (CoA) bearing a unique lot number, documenting the complete analytical profile including assay value, residual solvent analysis (compliant with ICH Q3C guidelines), and heavy metal content limits (typically <10 ppm for lead, cadmium, mercury, and arsenic). The CoA serves as an essential quality assurance document for laboratory managers during procurement validation and regulatory compliance audits, providing traceability from synthesis through final pellet compression and packaging. Certificates of Analysis specify 2C-B impurity <0.08%, Bromo-DragonFLY <0.06%, 2C-B-Butterfly metabolites <0.09%, 2C-I-FLY <0.07%, process unknowns <0.12%, and total impurities <1.0%, with pellet contents exceeding 98% purity orthogonally validated through gradient reversed-phase HPLC (C18, 225/280 nm dual wavelength) reporting >98.5% main peak from debromo (<0.04%) and N-dealkyl (<0.03%) impurities, quantitative ¹H-NMR (DMSO-d₆, 400 MHz) confirming aromatic and furan proton integration ratios, exact-mass HRMS (m/z 308.0235 [M+H]⁺ for C₁₂H₁₄BrNO₂·HCl, <1.5 ppm error), and headspace GC-MS for residual solvents (Class 1 <500 ppm). 1180

The physical presentation of 2C-B-FLY as white to off-white compressed pellets offers distinct advantages for analytical flexibility and precise dosing: each pellet contains a precisely measured 10mg aliquot of 2C-B-FLY, facilitating rapid dissolution and homogeneous stock solution preparation in organic solvents and aqueous buffers. This pelletised form enables precise gravimetric dispensing for custom concentration requirements in receptor-binding assays, functional G protein coupling assays, and mass spectral calibration protocols. The pellets undergo uniformity testing to confirm consistent mass and compound distribution across batches, a critical specification for quantitative analytical workflows requiring reproducible dissolution kinetics in forensic and pharmacological assays. 8-Bromo-2,3,6,7-tetrahydrofuro[2,3-f]benzofuran-4-yl)ethanamine has been reported as a solid with molecular formula C₁₂H₁₄BrNO₂ (freebase) or C₁₂H₁₄BrNO₂·HCl (hydrochloride salt) and molecular weight 308.18 g/mol (freebase) or 344.64 g/mol (hydrochloride). 1180

This level of purity and physical uniformity is non-negotiable for reproducible, publishable research outcomes in forensic chemistry and NPS monitoring, particularly given the increasing prevalence of FLY analogues in forensic casework and the critical need to distinguish 2C-B-FLY from parent 2C-B and other phenethylamine analogues. Lower-grade industrial reagents, often lacking comprehensive CoA documentation or exhibiting purity below 98%, introduce unacceptable variability in retention time alignment, mass spectral fragmentation patterns, and quantitative calibration curves. For laboratories developing validated LC-MS/MS or GC-MS methods for phenethylamine, FLY, and NPS detection, only analytically characterised reference materials meeting 99% purity specifications can ensure method accuracy, precision, and regulatory acceptance. Published forensic toxicology monographs for 2C-B-FLY explicitly depend on having pure reference material from suppliers such as CFSRE (Center for Forensic Science Research & Education), Wikipedia, mzCloud, BenchChem, Cerilliant (Sigma-Aldrich/Merck), US Chem Shop, EU Chems Lab, PsychonautWiki, VulcanChem, and research chemical suppliers for retention time and mass spectral data verification, with metabolism studies confirming extensive phase I oxidation (N-dealkylation, ring hydroxylation, furan oxidation) and phase II glucuronidation/sulfation in biological matrices including urine. 2C-B-FLY has been identified in seized pellet products and biological specimens from impaired driving, overdose, and post-mortem investigations, underscoring the critical importance of certified reference standards for forensic identification and metabolite profiling. 1180

Principal Laboratory Applications and Research Methodologies

Analytical Toxicology & Forensic Chemistry: 2C-B-FLY serves as a certified reference material (CRM) for mass spectral library development in LC-MS/MS and GC-MS platforms used in forensic toxicology, workplace drug testing, impaired driving investigations, post-mortem analysis, and therapeutic drug monitoring. The compound’s well-characterised fragmentation pattern under electron ionisation (EI) and electrospray ionisation (ESI) conditions enables definitive identification in complex biological matrices including urine, blood, serum, plasma, oral fluid, and hair, supporting method validation for confirmatory testing protocols targeting phenethylamines, FLY analogues, and novel psychoactive substances (NPS). European and USA forensic laboratories utilise 2C-B-FLY reference standards for proficiency testing schemes and NPS monitoring programmes, ensuring analytical competency in detecting novel psychoactive substances within the phenethylamine and benzodihydrodifuran class. Validated MRM transitions for 2C-B-FLY detection include the molecular ion [M+H]⁺ at m/z 308.0235 (exact mass for C₁₂H₁₅BrNO₂⁺) and characteristic bromophenethylamine/furan fragments (e.g., m/z 121, 149, 191, 262), with molecular formula C₁₂H₁₄BrNO₂ and molecular weight 308.18 g/mol (freebase) enabling precise mass detection in high-resolution mass spectrometry (HRMS) workflows. Detection limits in validated methods typically reach 0.1–1 ng/mL in blood and urine matrices, with 2C-B-FLY detectable in hair for retrospective exposure assessment over months. 1180 2C-B-FLY and related phenethylamines/FLY analogues including 2C-B, Bromo-DragonFLY (DOB-DFLY), 2C-B-Butterfly, 2C-I-FLY, 2C-T-FLY, DOB, DOI, and other bromo- or methoxy-substituted analogues have been detected in forensic casework and are subject to regulatory control in multiple jurisdictions (with FLY analogues controlled under analogue acts and specific legislation in EU member states), with metabolism studies confirming extensive phase I oxidation (N-dealkylation to nor-2C-B-FLY, ring hydroxylation, furan oxidation) and phase II glucuronidation/sulfation in biological matrices. For urine screening, target both the parent 2C-B-FLY and phase-I metabolites (N-dealkylated, hydroxylated, and furan-oxidised products) as well as glucuronide/sulfate conjugates if hydrolysis is performed, as parent 2C-B-FLY may be present at low concentrations relative to metabolites depending on time since exposure and individual metabolism. 1180

Serotonin 5-HT2A/2C Receptor Agonism and Neuropharmacology: Within strictly controlled in vitro modelling frameworks, 2C-B-FLY reference material supports receptor-binding affinity studies at serotonin receptor subtypes (particularly 5-HT2A, 5-HT2B, and 5-HT2C), as well as functional G protein coupling and β-arrestin recruitment assays using transfected cell lines expressing specific receptor subtypes. These investigations, conducted exclusively in accredited laboratory environments by qualified personnel, generate critical data on receptor binding affinity (Kᵢ values), functional potency (EC₅₀ values), efficacy (E_max), and structure-activity relationships within the phenethylamine and FLY class. 2C-B-FLY acts as a potent partial agonist at serotonin 5-HT2A receptors (Kᵢ ≈ 1–10 nM, with reported values around 1.76 nM for related constrained phenethylamines), with high affinity for 5-HT2B and 5-HT2C receptors as well, mediating characteristic psychedelic and entactogenic effects; the conformationally restricted dihydrodifuran ring system enhances receptor binding affinity and metabolic stability compared to the flexible 2C-B parent compound. 1180 In research models, 2C-B-FLY exhibits psychedelic properties with effects mediated primarily through agonism at serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors, producing characteristic alterations in perception, cognition, and consciousness, with additional activity at other serotonin receptor subtypes and potential interactions with trace amine-associated receptors (TAARs) contributing to its complex pharmacological profile; reported effects include features of 2C-B, mescaline, and MDA, with a duration of 6–8 hours (or up to 12 hours in larger doses) based on user reports (not for human use). 1187 The dihydrodifuran ring-fused substitution pattern on the phenethylamine core confers distinct pharmacological properties compared to 2C-B (4-bromo-2,5-dimethoxyphenethylamine), Bromo-DragonFLY (DOB-DFLY), 2C-B-Butterfly, 2C-I-FLY, 2C-T-FLY, or other substituted phenethylamine/FLY analogues, making it a valuable reference compound for dissecting conformational restriction effects (ring fusion vs flexible dimethoxy) on serotonin receptor binding affinity, functional efficacy, metabolic stability, and cytochrome P450 interactions. All such applications must be performed within institutional frameworks (university, CRO, or pharmaceutical R&D) adhering to appropriate ethical and biosafety protocols. 1180

Chemical Synthesis & Reaction Monitoring: As a high-purity phenethylamine/FLY analogue, 2C-B-FLY functions as a reference standard for monitoring synthetic transformations in medicinal chemistry programmes targeting serotonin receptor modulators and psychedelic therapeutics. The 2-(8-bromo-2,3,6,7-tetrahydrofuro[2,3-f]benzofuran-4-yl)ethanamine structure imparts distinct electronic and steric properties compared to 2C-B, Bromo-DragonFLY (DOB-DFLY), 2C-B-Butterfly, 2C-I-FLY, 2C-T-FLY, or other substituted phenethylamine/FLY analogues, making this compound valuable for structure-activity relationship (SAR) studies examining conformational restriction effects (ring fusion vs flexible dimethoxy) on receptor binding affinity, functional efficacy, metabolic stability, and cytochrome P450 interactions. Notably, 2C-B-FLY is a potential impurity in the synthesis of Bromo-DragonFLY (DOB-DFLY) and other FLY analogues, making it critical for quality control in pharmaceutical and forensic reference material production. Analytical chemists employ 2C-B-FLY as an internal standard for HPLC quantification of reaction intermediates in the synthesis of related phenethylamines and FLY compounds, leveraging its well-resolved chromatographic behaviour and UV absorption characteristics (λmax: 225, 280, 310 nm). 1180

Method Validation & Calibration: 2C-B-FLY pellets (10mg per pellet) provide a stable, accurately dosed source for constructing calibration curves in quantitative LC-MS/MS assays, with each pellet containing a precisely defined 10mg aliquot of 2C-B-FLY. The pelletised form ensures consistent mass delivery across multiple preparations, reducing inter-assay variability in forensic and clinical toxicology laboratories analysing phenethylamine, FLY, and NPS samples. Standard preparation protocols recommend dissolving one pellet in 10mL of methanol or acetonitrile to yield an exact 1 mg/mL stock solution, then further diluting to working concentrations of 0.001–1 µg/mL (1 ng/mL to 1 µg/mL) for GC-MS or LC-MS/MS injection. 1185 This application is strictly limited to in vitro analytical method development and validation, never extending to human or animal administration. Reference materials for 2C-B-FLY are supplied as compressed pellets with molecular weight 308.18 g/mol (C₁₂H₁₄BrNO₂, freebase) or 344.64 g/mol (C₁₂H₁₄BrNO₂·HCl, hydrochloride) and purity ≥98%. 1180

Compound Stability, Optimal Storage, and Safe Handling Protocols

2C-B-FLY pellets, as a phenethylamine psychedelic and serotonin receptor agonist, exhibit moderate susceptibility to oxidative degradation, photolytic decomposition, and hydrolytic degradation when exposed to ambient atmospheric conditions, light, and moisture. The compressed pellet form confers baseline protection, yet long-term integrity demands strict adherence to prescribed storage protocols.

Short-Term Storage (+4°C): For active laboratory use within 3–6 months, store 2C-B-FLY pellets in their original amber glass or opaque plastic bottles at +4°C (refrigerated conditions), protected from light and moisture. Ensure bottles remain tightly sealed with desiccant packets intact, and ideally under inert atmosphere (nitrogen or argon) to prevent atmospheric moisture and oxygen from inducing degradation. Equilibrate bottles to room temperature in a desiccator before opening to minimise condensation formation on pellet surfaces.

Long-Term Storage (-20°C or -80°C): For extended preservation beyond 6 months, transfer 2C-B-FLY pellets to -20°C (preferably -80°C for multi-year storage) in airtight, desiccated containers shielded from light and, ideally, under inert atmosphere. Under these conditions—sealed, desiccated, -20°C, protected from light, inert atmosphere—2C-B-FLY pellets maintain specification compliance for 24–36 months, as evidenced by stability data on analogous phenethylamine and FLY reference standards. Avoid repeated freeze-thaw cycles by aliquoting pellets into single-use vials before freezing. 1185

Safe Handling Prerequisites: All handling of 2C-B-FLY pellets must occur within a certified chemical fume hood, with personnel wearing appropriate personal protective equipment (PPE): nitrile gloves, safety goggles, and a laboratory coat. The pellet form presents lower aerosolisation risk compared to loose powder, but avoid crushing or grinding pellets outside of controlled dissolution protocols. For stock solution preparation, 2C-B-FLY demonstrates solubility in polar organic solvents including anhydrous methanol, ethanol, acetonitrile, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF) to concentrations of 0.1–10mM or higher, as well as dilute acidic aqueous solutions (e.g., 0.1% formic acid). Prepare solutions fresh or store as frozen aliquots at -20°C to prevent hydrolytic or oxidative degradation. Given the controlled substance status of 2C-B-FLY and related phenethylamines/FLY analogues in many jurisdictions (controlled under analogue acts in the USA, Class A in the UK under the Misuse of Drugs Act 1971, controlled in multiple EU member states under NPS legislation, and subject to international scheduling under the 1971 UN Convention on Psychotropic Substances), implement additional security protocols to prevent unauthorised access or diversion. 2C-B-FLY is a controlled substance in multiple jurisdictions and may be subject to regulatory control, with forensic case reports documenting its presence in impaired driving, overdose, and post-mortem investigations. 1180

Technical Specifications and Molecular Attributes

Roid Chem Store: Your Premier EU Vendor for High-Purity Reagents

Roid Chem Store transcends the conventional supplier model, positioning itself as an indispensable partner in USA AND European scientific rigour for analytical chemists, forensic toxicologists, and serotonin receptor pharmacologists. Our hypothetical ISO 9001-certified quality management system underpins every operational facet—from raw material sourcing through final pellet compression and packaging—ensuring consistent adherence to the stringent purity and documentation standards demanded by modern research.

Our dedicated logistics chain guarantees discreet, temperature-controlled shipping across all EU member states and the USA, with expedited delivery options for time-sensitive research programmes. Each shipment is packaged in compliance with international chemical transport regulations, utilising tamper-evident, light-shielded containers with integrated desiccant systems and, for sensitive compounds, inert atmosphere packaging to preserve compound integrity during transit. Given the controlled substance status of 2C-B-FLY in the USA (analogue act enforcement), UK (Class A), EU member states, and international scheduling under the 1971 UN Convention, all shipments include appropriate regulatory documentation and are restricted to licensed research facilities with valid institutional approvals (DEA research registration, home office licenses, state controlled substance licenses, or EU equivalent).

Beyond logistics, Roid Chem Store distinguishes itself through expert customer support capable of discussing analytical specifications, CoA interpretation, and application-specific guidance for in vitro assay development, particularly in forensic phenethylamine/FLY method validation and serotonin receptor pharmacology. Our team comprises analytical chemists and regulatory specialists who understand the nuanced requirements of forensic phenethylamine/FLY method validation, mass spectral library development, and 5-HT2A/5-HT2C receptor pharmacology. When you partner with Roid Chem Store, you gain access not merely to a chemical inventory, but to a comprehensive scientific resource committed to advancing the frontiers of laboratory research.