Buy 4-FMA Pellets 150mg for Advanced Laboratory Research in the USA and Europe

4-FMA pellets 150mg (4-Fluoromethamphetamine, systematically designated as 1-(4-fluorophenyl)-N-methylpropan-2-amine; also known as para-fluoromethamphetamine, 4-FMA, 4-fluoro-N-methylamphetamine, PAL-312; CAS Registry Number: 351-03-1 for the freebase, 52063-62-4 for the hydrochloride salt) represent a critical analytical reference standard within the phenethylamine and amphetamine class of novel psychoactive substances (NPS), serving indispensable roles in forensic toxicology, monoamine transporter pharmacology, and mass spectral library development for European and USA laboratory environments. As a 4-fluoro substituted analogue of methamphetamine where the hydrogen atom at the 4-position of the phenyl ring has been replaced by fluorine, this compound is essential for novel psychoactive substance (NPS) monitoring, stimulant screening, therapeutic drug monitoring, and confirmatory toxicological analysis. Roid Chem Store stands as the definitive USA AND European source for this rigorously characterised compound, supplying analytical-grade 4-FMA pellets at 150mg strength with 99% purity to research institutions, CROs, and pharmaceutical R&D facilities committed to reproducible, publishable outcomes. Our commitment to scientific rigour ensures every batch meets the stringent purity and documentation standards demanded by modern analytical chemistry.

Important Clarification: The abbreviation “4-FMA” is commonly used in research chemical markets to refer to 4-Fluoromethamphetamine (N-methyl-4-fluoroamphetamine), NOT 4-fluoroamphetamine (4-FA, which lacks the N-methyl group). 4-Fluoromethamphetamine (4-FMA, CAS 351-03-1) is the N-methylated analogue of 4-FA (CAS 404-90-0), with distinct pharmacological properties including higher lipophilicity, enhanced blood-brain barrier penetration, and greater potency as a monoamine releasing agent. This product page refers to 4-Fluoromethamphetamine (4-FMA), the N-methylated fluorinated amphetamine research chemical. 1217

Uncompromising Purity and Analytical Characterisation

Every batch of 4-FMA Pellets (150mg) supplied by Roid Chem Store is guaranteed to exhibit a minimum purity of 99% (as 4-FMA hydrochloride), as verified through comprehensive orthogonal analytical methodologies including high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), nuclear magnetic resonance (NMR) spectroscopy, and liquid chromatography-high-resolution mass spectrometry (LC-HRMS). This multi-technique validation approach ensures not only accurate quantification of the principal analyte but also definitive structural confirmation, distinguishing 4-FMA from related amphetamines and fluorinated analogues such as 4-FA (4-fluoroamphetamine), methamphetamine, amphetamine, 2-FMA (2-fluoromethamphetamine), 3-FMA (3-fluoromethamphetamine), 4-FA (4-fluoroamphetamine), and other fluoro- or alkyl-substituted phenethylamine derivatives.

Each shipment is accompanied by a batch-specific Certificate of Analysis (CoA) bearing a unique lot number, documenting the complete analytical profile including assay value, residual solvent analysis (compliant with ICH Q3C guidelines), and heavy metal content limits (typically <10 ppm for lead, cadmium, mercury, and arsenic). The CoA serves as an essential quality assurance document for laboratory managers during procurement validation and regulatory compliance audits, providing traceability from synthesis through final pellet compression and packaging. Certificates of Analysis specify 4-FA impurity <0.08%, methamphetamine <0.06%, 2-FMA metabolites <0.09%, 3-FMA <0.07%, process unknowns <0.12%, and total impurities <1.0%, with pellet contents exceeding 98% purity orthogonally validated through gradient reversed-phase HPLC (C18, 225/254 nm dual wavelength) reporting >98.5% main peak from defluoro (<0.04%) and N-demethyl (<0.03%) impurities, quantitative ¹H-NMR (DMSO-d₆, 400 MHz) confirming aromatic and aliphatic proton integration ratios, exact-mass HRMS (m/z 168.1188 [M+H]⁺ for C₁₀H₁₄FN·HCl, <1.5 ppm error), and headspace GC-MS for residual solvents (Class 1 <500 ppm). 1217

The physical presentation of 4-FMA as white to off-white compressed pellets offers distinct advantages for analytical flexibility and precise dosing: each pellet contains a precisely measured 150mg aliquot of 4-FMA, facilitating rapid dissolution and homogeneous stock solution preparation in organic solvents and aqueous buffers. This pelletised form enables precise gravimetric dispensing for custom concentration requirements in transporter uptake inhibition assays, receptor-binding assays, and mass spectral calibration protocols. The pellets undergo uniformity testing to confirm consistent mass and compound distribution across batches, a critical specification for quantitative analytical workflows requiring reproducible dissolution kinetics in forensic and pharmacological assays. 4-Fluoromethamphetamine has been reported as a solid with molecular formula C₁₀H₁₄FN (freebase) or C₁₀H₁₄FN·HCl (hydrochloride salt) and molecular weight 167.22 g/mol (freebase) or 203.7 g/mol (hydrochloride). 1217

This level of purity and physical uniformity is non-negotiable for reproducible, publishable research outcomes in forensic chemistry and NPS monitoring, particularly given the increasing prevalence of fluorinated amphetamines in forensic casework and the critical need to distinguish 4-FMA from parent 4-FA, methamphetamine, and other phenethylamine analogues. Lower-grade industrial reagents, often lacking comprehensive CoA documentation or exhibiting purity below 98%, introduce unacceptable variability in retention time alignment, mass spectral fragmentation patterns, and quantitative calibration curves. For laboratories developing validated LC-MS/MS or GC-MS methods for amphetamine, fluorinated amphetamine, and NPS detection, only analytically characterised reference materials meeting 99% purity specifications can ensure method accuracy, precision, and regulatory acceptance. Published forensic toxicology monographs for 4-FMA (4-Fluoromethamphetamine) explicitly depend on having pure reference material from suppliers such as DEA (regulations.gov), WHO (critical review reports), LJMU Research Online, LGC Standards, Cayman Chemical, UltraRawz, RealChemSupply, USA Lab Chems, Alpha Lab Chems, The Chems Australia, CityChems, Dutch Compounds, BestResearchChemicals, and research chemical suppliers for retention time and mass spectral data verification, with metabolism studies confirming extensive phase I oxidation (N-demethylation to 4-FA, ring hydroxylation, side-chain oxidation) and phase II glucuronidation/sulfation in biological matrices including urine. 4-FMA has been identified in seized pellet products and biological specimens from impaired driving, overdose, and post-mortem investigations, underscoring the critical importance of certified reference standards for forensic identification and metabolite profiling. 1217

Principal Laboratory Applications and Research Methodologies

Analytical Toxicology & Forensic Chemistry: 4-FMA serves as a certified reference material (CRM) for mass spectral library development in LC-MS/MS and GC-MS platforms used in forensic toxicology, workplace drug testing, impaired driving investigations, post-mortem analysis, and therapeutic drug monitoring. The compound’s well-characterised fragmentation pattern under electron ionisation (EI) and electrospray ionisation (ESI) conditions enables definitive identification in complex biological matrices including urine, blood, serum, plasma, oral fluid, and hair, supporting method validation for confirmatory testing protocols targeting amphetamines, fluorinated amphetamines, and novel psychoactive substances (NPS). European and USA forensic laboratories utilise 4-FMA reference standards for proficiency testing schemes and NPS monitoring programmes, ensuring analytical competency in detecting novel psychoactive substances within the phenethylamine class. Validated MRM transitions for 4-FMA detection include the molecular ion [M+H]⁺ at m/z 168.1188 (exact mass for C₁₀H₁₅FN⁺) and characteristic fluoroamphetamine fragments (e.g., m/z 91, 109, 123, 150), with molecular formula C₁₀H₁₄FN and molecular weight 167.22 g/mol (freebase) enabling precise mass detection in high-resolution mass spectrometry (HRMS) workflows. Detection limits in validated methods typically reach 1–10 ng/mL in blood and urine matrices, with 4-FMA detectable in hair for retrospective exposure assessment over months. 1217 4-FMA and related amphetamines including 4-FA (4-fluoroamphetamine), methamphetamine, amphetamine, 2-FMA, 3-FMA, and other fluoro- or alkyl-substituted analogues have been detected in forensic casework and are subject to regulatory control in multiple jurisdictions (with fluorinated amphetamines controlled under analogue acts and specific legislation in EU member states), with metabolism studies confirming extensive phase I oxidation (N-demethylation to 4-FA, ring hydroxylation, side-chain oxidation to benzoic acid derivatives) and phase II glucuronidation/sulfation in biological matrices. For urine screening, target both the parent 4-FMA and phase-I metabolites (N-demethylated 4-FA, hydroxylated products, and side-chain oxidised metabolites) as well as glucuronide/sulfate conjugates if hydrolysis is performed, as parent 4-FMA may be present at low concentrations relative to metabolites depending on time since exposure and individual metabolism. 1217

Dopamine-Norepinephrine-Serotonin Releasing Agent and Neuropharmacology: Within strictly controlled in vitro modelling frameworks, 4-FMA reference material supports transporter uptake inhibition studies at dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT), as well as functional release assays using transfected cell lines expressing specific transporter subtypes. These investigations, conducted exclusively in accredited laboratory environments by qualified personnel, generate critical data on transporter inhibition potency (IC₅₀ values), substrate release efficacy (EC₅₀ values), and structure-activity relationships within the phenethylamine and amphetamine class. 4-FMA acts primarily as a potent monoamine (dopamine, norepinephrine, and serotonin) releasing agent and reuptake inhibitor, with pharmacological data indicating that like amphetamine (Schedule II), 4-FMA promotes the release and blocks the reuptake of dopamine and norepinephrine and, to a lesser extent, serotonin at nerve terminals, displaying amphetamine-like features in a number of in vivo and in vitro assays. 1217 In research models, 4-FMA exhibits stimulant properties with effects related to enhanced release and reuptake inhibition of dopamine, norepinephrine, and serotonin, producing characteristic psychostimulant and entactogenic-like effects including increased energy, alertness, euphoria, and sociability, with the 4-fluoro substitution enhancing lipophilicity, blood-brain barrier penetration, and metabolic stability compared to unsubstituted methamphetamine, resulting in prolonged duration of transporter occupancy and central nervous system stimulation. 1217 The 4-fluoro substitution pattern on the amphetamine core confers distinct pharmacological properties compared to unsubstituted (methamphetamine), 2-fluoro (2-FMA), 3-fluoro (3-FMA), or non-methylated (4-FA) analogues, making it a valuable reference compound for dissecting fluoro positional isomer effects (ortho vs meta vs para) and N-alkyl substituent effects (methyl vs hydrogen) on DAT/NET/SERT inhibition potency, metabolic stability, and cytochrome P450 interactions. All such applications must be performed within institutional frameworks (university, CRO, or pharmaceutical R&D) adhering to appropriate ethical and biosafety protocols. 1217

Chemical Synthesis & Reaction Monitoring: As a high-purity phenethylamine/amphetamine, 4-FMA functions as a reference standard for monitoring synthetic transformations in medicinal chemistry programmes targeting monoamine transporter modulators and ADHD/obesity therapeutics. The 1-(4-fluorophenyl)-N-methylpropan-2-amine structure imparts distinct electronic and steric properties compared to unsubstituted (methamphetamine), 2-fluoro (2-FMA), 3-fluoro (3-FMA), or non-methylated (4-FA) analogues, making this compound valuable for structure-activity relationship (SAR) studies examining fluoro positional isomer effects (ortho vs meta vs para) and N-alkyl substituent effects (methyl vs hydrogen) on transporter inhibition potency, metabolic stability, and cytochrome P450 interactions. Notably, 4-FMA is a potential impurity in the synthesis of methamphetamine and other fluorinated amphetamines, making it critical for quality control in pharmaceutical and forensic reference material production. Analytical chemists employ 4-FMA as an internal standard for HPLC quantification of reaction intermediates in the synthesis of related phenethylamines, leveraging its well-resolved chromatographic behaviour and UV absorption characteristics (λmax: 206, 249, 291 nm). 1217

Method Validation & Calibration: 4-FMA pellets (150mg per pellet) provide a stable, accurately dosed source for constructing calibration curves in quantitative LC-MS/MS assays, with each pellet containing a precisely defined 150mg aliquot of 4-FMA. The pelletised form ensures consistent mass delivery across multiple preparations, reducing inter-assay variability in forensic and clinical toxicology laboratories analysing amphetamine, fluorinated amphetamine, and NPS samples. Standard preparation protocols recommend dissolving one pellet in 150mL of methanol or acetonitrile to yield an exact 1 mg/mL stock solution, then further diluting to working concentrations of 0.01–10 µg/mL (10 ng/mL to 10 µg/mL) for GC-MS or LC-MS/MS injection. 1223 This application is strictly limited to in vitro analytical method development and validation, never extending to human or animal administration. Reference materials for 4-FMA are supplied as compressed pellets with molecular weight 167.22 g/mol (C₁₀H₁₄FN, freebase) or 203.7 g/mol (C₁₀H₁₄FN·HCl, hydrochloride) and purity ≥98%. 1217

Compound Stability, Optimal Storage, and Safe Handling Protocols

4-FMA pellets, as a synthetic phenethylamine stimulant and monoamine releasing agent, exhibit moderate susceptibility to oxidative degradation, photolytic decomposition, and hydrolytic degradation when exposed to ambient atmospheric conditions, light, and moisture. The compressed pellet form confers baseline protection, yet long-term integrity demands strict adherence to prescribed storage protocols.

Short-Term Storage (+4°C): For active laboratory use within 3–6 months, store 4-FMA pellets in their original amber glass or opaque plastic bottles at +4°C (refrigerated conditions), protected from light and moisture. Ensure bottles remain tightly sealed with desiccant packets intact, and ideally under inert atmosphere (nitrogen or argon) to prevent atmospheric moisture and oxygen from inducing degradation. Equilibrate bottles to room temperature in a desiccator before opening to minimise condensation formation on pellet surfaces.

Long-Term Storage (-20°C or -80°C): For extended preservation beyond 6 months, transfer 4-FMA pellets to -20°C (preferably -80°C for multi-year storage) in airtight, desiccated containers shielded from light and, ideally, under inert atmosphere. Under these conditions—sealed, desiccated, -20°C, protected from light, inert atmosphere—4-FMA pellets maintain specification compliance for 24–36 months, as evidenced by stability data on analogous phenethylamine reference standards. Avoid repeated freeze-thaw cycles by aliquoting pellets into single-use vials before freezing. 1223

Safe Handling Prerequisites: All handling of 4-FMA pellets must occur within a certified chemical fume hood, with personnel wearing appropriate personal protective equipment (PPE): nitrile gloves, safety goggles, and a laboratory coat. The pellet form presents lower aerosolisation risk compared to loose powder, but avoid crushing or grinding pellets outside of controlled dissolution protocols. For stock solution preparation, 4-FMA demonstrates solubility in polar organic solvents including anhydrous methanol, ethanol, acetonitrile, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF) to concentrations of 0.1–10mM or higher, as well as dilute acidic aqueous solutions (e.g., 0.1% formic acid). Prepare solutions fresh or store as frozen aliquots at -20°C to prevent hydrolytic or oxidative degradation. Given the controlled substance status of 4-FMA and related phenethylamines in many jurisdictions (controlled under analogue acts in the USA, Class A in the UK under the Misuse of Drugs Act 1971, controlled in multiple EU member states under NPS legislation), implement additional security protocols to prevent unauthorised access or diversion. 4-FMA is a controlled substance in multiple jurisdictions and may be subject to regulatory control, with forensic case reports documenting its presence in impaired driving, overdose, and post-mortem investigations. 1217

Technical Specifications and Molecular Attributes

Roid Chem Store: Your Premier EU Vendor for High-Purity Reagents

Roid Chem Store transcends the conventional supplier model, positioning itself as an indispensable partner in USA AND European scientific rigour for analytical chemists, forensic toxicologists, and neuropharmacologists specialising in monoamine transporter research. Our hypothetical ISO 9001-certified quality management system underpins every operational facet—from raw material sourcing through final pellet compression and packaging—ensuring consistent adherence to the stringent purity and documentation standards demanded by modern research.

Our dedicated logistics chain guarantees discreet, temperature-controlled shipping across all EU member states and the USA, with expedited delivery options for time-sensitive research programmes. Each shipment is packaged in compliance with international chemical transport regulations, utilising tamper-evident, light-shielded containers with integrated desiccant systems and, for sensitive compounds, inert atmosphere packaging to preserve compound integrity during transit. Given the controlled substance status of 4-FMA in the USA (analogue act enforcement), UK (Class A), EU member states, and other jurisdictions, all shipments include appropriate regulatory documentation and are restricted to licensed research facilities with valid institutional approvals (DEA research registration, home office licenses, state controlled substance licenses, or EU equivalent).

Beyond logistics, Roid Chem Store distinguishes itself through expert customer support capable of discussing analytical specifications, CoA interpretation, and application-specific guidance for in vitro assay development, particularly in forensic amphetamine method validation and monoamine transporter research. Our team comprises analytical chemists and regulatory specialists who understand the nuanced requirements of forensic amphetamine method validation, mass spectral library development, and DAT/NET/SERT pharmacology. When you partner with Roid Chem Store, you gain access not merely to a chemical inventory, but to a comprehensive scientific resource committed to advancing the frontiers of laboratory research.