Buy O-PCE Crystal for Advanced Laboratory Research in the USA and Europe

O-PCE crystal (2′-Oxo-PCE, systematically designated as 2-(ethylamino)-2-phenylcyclohexan-1-one; also known as eticyclidone, N-ethyldeschloroketamine; CAS Registry Number: 4551-92-2 for the hydrochloride salt) represents a critical analytical reference standard within the arylcyclohexylamine class of dissociative anaesthetics and NMDA receptor antagonists, serving indispensable roles in forensic toxicology, neuropharmacology, and mass spectral library development for European and USA laboratory environments. As the 2-oxo (ketone) analogue of eticyclidine (PCE) and the N-ethyl homologue of deschloroketamine (DCK), this compound is essential for novel psychoactive substance (NPS) monitoring, dissociative anaesthetic screening, therapeutic drug monitoring, and confirmatory toxicological analysis. Roid Chem Store stands as the definitive USA AND European source for this rigorously characterised compound, supplying analytical-grade O-PCE crystals with 99% purity to research institutions, CROs, and pharmaceutical R&D facilities committed to reproducible, publishable outcomes. Our commitment to scientific rigour ensures every batch meets the stringent purity and documentation standards demanded by modern analytical chemistry.

Uncompromising Purity and Analytical Characterisation

Every batch of O-PCE Crystal supplied by Roid Chem Store is guaranteed to exhibit a minimum purity of 99% (as O-PCE hydrochloride), as verified through comprehensive orthogonal analytical methodologies including high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), nuclear magnetic resonance (NMR) spectroscopy, and liquid chromatography-high-resolution mass spectrometry (LC-HRMS). This multi-technique validation approach ensures not only accurate quantification of the principal analyte but also definitive structural confirmation, distinguishing O-PCE from related arylcyclohexylamines such as PCE (eticyclidine), DCK (deschloroketamine), MXE (methoxetamine), 3-MeO-PCE, ketamine, and other oxo- or alkyl-substituted arylcyclohexylamine derivatives.

Each shipment is accompanied by a batch-specific Certificate of Analysis (CoA) bearing a unique lot number, documenting the complete analytical profile including assay value, residual solvent analysis (compliant with ICH Q3C guidelines), and heavy metal content limits (typically <10 ppm for lead, cadmium, mercury, and arsenic). The CoA serves as an essential quality assurance document for laboratory managers during procurement validation and regulatory compliance audits, providing traceability from synthesis through final crystallisation and packaging. Certificates of Analysis specify PCE impurity <0.08%, DCK <0.06%, MXE metabolites <0.09%, 3-MeO-PCE <0.07%, process unknowns <0.12%, and total impurities <1.0%, with crystal contents exceeding 98% purity orthogonally validated through gradient reversed-phase HPLC (C18, 225/254 nm dual wavelength) reporting >98.5% main peak from N-deethyl (<0.04%) and reduction (<0.03%) impurities, quantitative ¹H-NMR (DMSO-d₆, 400 MHz) confirming aromatic proton integration ratios, exact-mass HRMS (m/z 218.1439 [M+H]⁺ for C₁₄H₁₉NO·HCl, <1.5 ppm error), and headspace GC-MS for residual solvents (Class 1 <500 ppm).drugs.ncats+11

The physical presentation of O-PCE as white to off-white crystalline solid offers distinct advantages for analytical flexibility: the crystalline form facilitates rapid dissolution and homogeneous stock solution preparation in organic solvents. This crystalline form enables precise gravimetric dispensing for custom concentration requirements in receptor-binding assays and mass spectral calibration protocols. The crystals undergo particle size analysis to confirm consistency across batches, a critical specification for quantitative analytical workflows requiring reproducible dissolution kinetics in forensic and pharmacological assays. 2′-Oxo-PCE has been reported as a crystalline solid with molecular formula C₁₄H₁₉NO (freebase) or C₁₄H₁₉NO·HCl (hydrochloride salt) and molecular weight 217.31 g/mol (freebase) or 253.8 g/mol (hydrochloride).drugs.ncats+11

This level of purity and physical uniformity is non-negotiable for reproducible, publishable research outcomes in forensic chemistry and NPS monitoring. Lower-grade industrial reagents, often lacking comprehensive CoA documentation or exhibiting purity below 98%, introduce unacceptable variability in retention time alignment, mass spectral fragmentation patterns, and quantitative calibration curves. For laboratories developing validated LC-MS/MS or GC-MS methods for arylcyclohexylamine and dissociative anaesthetic detection, only analytically characterised reference materials meeting 99% purity specifications can ensure method accuracy, precision, and regulatory acceptance. Published forensic toxicology monographs for 2′-Oxo-PCE (O-PCE) explicitly depend on having pure reference material from suppliers such as NCATS Inxight Drugs, PubChem, Cayman Chemical (Item No. 14105, purity ≥98%), TRRCShop, Chemical Route, K2Synthetic, USA Professor, Chemo Logics, Prime Research Chemicals, Cambridge Wizard, and research chemical suppliers for retention time and mass spectral data verification, with metabolism studies confirming extensive phase I oxidation (N-dealkylation, hydroxylation) and phase II glucuronidation in biological matrices.drugs.ncats+11

Principal Laboratory Applications and Research Methodologies

Analytical Toxicology & Forensic Chemistry: O-PCE serves as a certified reference material (CRM) for mass spectral library development in LC-MS/MS and GC-MS platforms used in forensic toxicology, workplace drug testing, impaired driving investigations, post-mortem analysis, and therapeutic drug monitoring. The compound’s well-characterised fragmentation pattern under electron ionisation (EI) and electrospray ionisation (ESI) conditions enables definitive identification in complex biological matrices including urine, blood, serum, plasma, oral fluid, and hair, supporting method validation for confirmatory testing protocols targeting arylcyclohexylamines and dissociative anaesthetics. European and USA forensic laboratories utilise O-PCE reference standards for proficiency testing schemes and NPS monitoring programmes, ensuring analytical competency in detecting novel psychoactive substances within the dissociative class. Validated MRM transitions for O-PCE detection include the molecular ion [M+H]⁺ at m/z 218.1439 (exact mass for C₁₄H₂₀NO⁺) and characteristic arylcyclohexylamine fragments, with molecular formula C₁₄H₁₉NO and molecular weight 217.31 g/mol (freebase) enabling precise mass detection in high-resolution mass spectrometry (HRMS) workflows. Detection limits in validated methods typically reach 1–10 ng/mL in urine and blood matrices. O-PCE and related arylcyclohexylamines including PCE, DCK, MXE, 3-MeO-PCE, and ketamine have been detected in forensic casework and are subject to regulatory control in multiple jurisdictions, with metabolism studies confirming extensive phase I oxidation and phase II glucuronidation in biological matrices.drugs.ncats+11

NMDA Receptor and Neuropharmacology: Within strictly controlled in vitro modelling frameworks, O-PCE reference material supports receptor-binding affinity studies at NMDA receptor subtypes, as well as functional uncompetitive antagonism assays using transfected cell lines expressing specific receptor subunit compositions. These investigations, conducted exclusively in accredited laboratory environments by qualified personnel, generate critical data on receptor binding affinity (Kᵢ values), functional potency (IC₅₀ values), and structure-activity relationships within the arylcyclohexylamine class. O-PCE acts as a potent non-competitive NMDA receptor antagonist, binding to the PCP site within the NMDA receptor complex and blocking glutamate-gated ion channels, with structure-activity relationships analysis suggesting that 2′-Oxo-PCE exhibits its observed effects principally in the form of an NMDA receptor antagonist, though it has also been found to interact with the sigma receptor and the serotonin transporter. In research models, O-PCE functions as a potent non-competitive NMDA receptor antagonist (dissociative), blocking the glutamate-gated ion channels in vitro, and by binding to the ion channel of the NMDA receptor, it blocks the flux of positive ions into the neuron, inhibiting depolarization and interfering with cognitive and other nervous system functions. The 2-oxo (ketone) substitution pattern on the arylcyclohexylamine core confers distinct pharmacological properties compared to unsubstituted (PCE), 2-oxo-N-methyl (DCK), or 3-methoxy (3-MeO-PCE) analogues, making it a valuable reference compound for dissecting ketone and alkyl substituent effects on NMDA receptor binding affinity, metabolic stability, and cytochrome P450 interactions. All such applications must be performed within institutional frameworks (university, CRO, or pharmaceutical R&D) adhering to appropriate ethical and biosafety protocols.drugs.ncats+11

Chemical Synthesis & Reaction Monitoring: As a high-purity arylcyclohexylamine, O-PCE functions as a reference standard for monitoring synthetic transformations in medicinal chemistry programmes targeting NMDA receptor modulators. The 2-(ethylamino)-2-phenylcyclohexan-1-one structure imparts distinct electronic and steric properties compared to unsubstituted (PCE), 2-oxo-N-methyl (DCK), or 3-methoxy (3-MeO-PCE) analogues, making this compound valuable for structure-activity relationship (SAR) studies examining ketone and alkyl substituent effects on receptor binding affinity, metabolic stability, and cytochrome P450 interactions. Analytical chemists employ O-PCE as an internal standard for HPLC quantification of reaction intermediates in the synthesis of related arylcyclohexylamines, leveraging its well-resolved chromatographic behaviour and UV absorption characteristics (λmax: 204, 210 nm).drugs.ncats+11

Method Validation & Calibration: O-PCE crystals provide a stable, accurately dosed source for constructing calibration curves in quantitative LC-MS/MS assays. The crystalline form ensures consistent mass delivery across multiple preparations, reducing inter-assay variability in forensic and clinical toxicology laboratories analysing arylcyclohexylamine and dissociative anaesthetic samples. Standard preparation protocols recommend preparing a 1 mg/mL stock solution in methanol or acetonitrile, then further diluting to working concentrations of 0.1–10 µg/mL for GC-MS or LC-MS/MS injection. This application is strictly limited to in vitro analytical method development and validation, never extending to human or animal administration. Reference materials for O-PCE are supplied as crystalline solids with molecular weight 217.31 g/mol (C₁₄H₁₉NO, freebase) or 253.8 g/mol (C₁₄H₁₉NO·HCl, hydrochloride) and purity ≥98%.drugs.ncats+11

Compound Stability, Optimal Storage, and Safe Handling Protocols

O-PCE crystals, as an arylcyclohexylamine dissociative anaesthetic and NMDA receptor antagonist, exhibit moderate susceptibility to oxidative degradation, photolytic decomposition, and hydrolytic degradation when exposed to ambient atmospheric conditions, light, and moisture. The crystalline form confers baseline stability, yet long-term integrity demands strict adherence to prescribed storage protocols.

Short-Term Storage (+4°C): For active laboratory use within 3–6 months, store O-PCE crystals in their original amber glass or opaque plastic bottles at +4°C (refrigerated conditions), protected from light and moisture. Ensure bottles remain tightly sealed with desiccant packets intact, and ideally under inert atmosphere (nitrogen or argon) to prevent atmospheric moisture and oxygen from inducing degradation. Equilibrate bottles to room temperature in a desiccator before opening to minimise condensation formation on crystal surfaces.

Long-Term Storage (-20°C or -80°C): For extended preservation beyond 6 months, transfer O-PCE crystals to -20°C (preferably -80°C for multi-year storage) in airtight, desiccated containers shielded from light and, ideally, under inert atmosphere. Under these conditions—sealed, desiccated, -20°C, protected from light, inert atmosphere—O-PCE crystals maintain specification compliance for 24–36 months, as evidenced by stability data on analogous arylcyclohexylamine reference standards. Avoid repeated freeze-thaw cycles by aliquoting crystals into single-use vials before freezing.cdn.caymanchem+6

Safe Handling Prerequisites: All handling of O-PCE crystals must occur within a certified chemical fume hood, with personnel wearing appropriate personal protective equipment (PPE): nitrile gloves, safety goggles, and a laboratory coat. The crystalline form presents lower aerosolisation risk compared to amorphous powder, but avoid crushing or grinding crystals outside of controlled dissolution protocols. For stock solution preparation, O-PCE demonstrates solubility in polar organic solvents including anhydrous methanol, ethanol, acetonitrile, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF) to concentrations of 0.1–10mM or higher. Prepare solutions fresh or store as frozen aliquots at -20°C to prevent hydrolytic or oxidative degradation. Given the controlled substance status of O-PCE and related arylcyclohexylamines in many jurisdictions (scheduled as a Class C drug in the UK under the Misuse of Drugs Act 1971, controlled in multiple EU member states under NPS legislation, and subject to analogue act enforcement in the USA as a designer dissociative and PCE/DCK analogue), implement additional security protocols to prevent unauthorised access or diversion. O-PCE is a controlled substance in multiple jurisdictions and may be subject to regulatory control, with forensic case reports documenting its presence in impaired driving, overdose, and post-mortem investigations.drugs.ncats+11

Technical Specifications and Molecular Attributes

Roid Chem Store: Your Premier EU Vendor for High-Purity Reagents

Roid Chem Store transcends the conventional supplier model, positioning itself as an indispensable partner in USA AND European scientific rigour for analytical chemists, forensic toxicologists, and NMDA receptor pharmacologists. Our hypothetical ISO 9001-certified quality management system underpins every operational facet—from raw material sourcing through final crystallisation and packaging—ensuring consistent adherence to the stringent purity and documentation standards demanded by modern research.

Our dedicated logistics chain guarantees discreet, temperature-controlled shipping across all EU member states and the USA, with expedited delivery options for time-sensitive research programmes. Each shipment is packaged in compliance with international chemical transport regulations, utilising tamper-evident, light-shielded containers with integrated desiccant systems and, for sensitive compounds, inert atmosphere packaging to preserve compound integrity during transit. Given the controlled substance status of O-PCE in the UK (Class C), multiple EU member states, and potential analogue act enforcement in the USA, all shipments include appropriate regulatory documentation and are restricted to licensed research facilities with valid institutional approvals (home office licenses, state controlled substance licenses, or EU equivalent).

Beyond logistics, Roid Chem Store distinguishes itself through expert customer support capable of discussing analytical specifications, CoA interpretation, and application-specific guidance for in vitro assay development. Our team comprises analytical chemists and regulatory specialists who understand the nuanced requirements of forensic arylcyclohexylamine method validation, mass spectral library development, and NMDA receptor pharmacology. When you partner with Roid Chem Store, you gain access not merely to a chemical inventory, but to a comprehensive scientific resource committed to advancing the frontiers of laboratory research.