Buy 5-MAPB Powder for Advanced Laboratory Research in the USA and Europe

5-MAPB powder (systematically designated as 5-(2-methylaminopropyl)benzofuran, 5-(N-methyl-2-aminopropyl)benzofuran, or 1-(benzofuran-5-yl)-N-methylpropan-2-amine; CAS Registry Number: 1354631-77-8 for freebase, 1823925-53-6 for hydrochloride salt) represents a critical analytical reference standard within the substituted benzofuran entactogen class, serving indispensable roles in forensic toxicology, monoamine transporter pharmacology, and mass spectral library development for European and USA laboratory environments. As the N-methylated analogue of 5-APB and a structural relative of 6-APB, 6-MAPB, MDA, and MDMA, this compound is essential for novel psychoactive substance (NPS) monitoring, serotonin-norepinephrine-dopamine releasing agent (SNDRA) research, and confirmatory toxicological screening. Roid Chem Store stands as the definitive USA AND European source for this rigorously characterised compound, supplying analytical-grade 5-MAPB powder at 99% purity to research institutions, CROs, and pharmaceutical R&D facilities committed to reproducible, publishable outcomes. Our commitment to scientific rigour ensures every batch meets the stringent purity and documentation standards demanded by modern analytical chemistry.

Uncompromising Purity and Analytical Characterisation

Every batch of 5-MAPB Powder supplied by Roid Chem Store is guaranteed to exhibit a minimum purity of 99% (as 5-MAPB hydrochloride), as verified through comprehensive orthogonal analytical methodologies including high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), nuclear magnetic resonance (NMR) spectroscopy, and Fourier-transform infrared spectroscopy (FTIR). This multi-technique validation approach ensures not only accurate quantification of the principal analyte but also definitive structural confirmation, distinguishing 5-MAPB from related benzofuran entactogens such as 5-APB, 6-APB, 6-MAPB, 5-EAPB, MDA, and other N-methylated or N-alkylated benzofuran derivatives.

Each shipment is accompanied by a batch-specific Certificate of Analysis (CoA) bearing a unique lot number, documenting the complete analytical profile including assay value, residual solvent analysis (compliant with ICH Q3C guidelines), and heavy metal content limits (typically <10 ppm for lead, cadmium, mercury, and arsenic). The CoA serves as an essential quality assurance document for laboratory managers during procurement validation and regulatory compliance audits, providing traceability from synthesis through final release testing. Certified reference materials for 5-MAPB hydrochloride are available from suppliers such as Cayman Chemical (Product No. 14109) with chromatographic purity ≥98%, underscoring the importance of high-purity standards for forensic and research applications.pmc.ncbi.nlm.nih+4

The physical presentation of 5-MAPB as a white to off-white crystalline hydrochloride salt powder offers distinct advantages for analytical flexibility: the compound presents as a microcrystalline or amorphous solid with consistent particle size distribution, facilitating rapid dissolution and homogeneous stock solution preparation in aqueous and organic solvents. This powdered form enables precise gravimetric dispensing for custom concentration requirements in transporter-binding assays and mass spectral calibration protocols. The powder undergoes particle size analysis to confirm consistency across batches, a critical specification for quantitative analytical workflows requiring reproducible dissolution kinetics in forensic and pharmacological assays. 5-MAPB hydrochloride has been reported as a crystalline solid with molecular formula C₁₂H₁₅NO·HCl and molecular weight 225.72 g/mol (freebase C₁₂H₁₅NO, MW 189.25 g/mol).pmc.ncbi.nlm.nih+3

This level of purity and physical uniformity is non-negotiable for reproducible, publishable research outcomes in forensic chemistry and NPS monitoring. Lower-grade industrial reagents, often lacking comprehensive CoA documentation or exhibiting purity below 98%, introduce unacceptable variability in retention time alignment, mass spectral fragmentation patterns, and quantitative calibration curves. For laboratories developing validated LC-MS/MS or GC-MS methods for benzofuran entactogen detection, only analytically characterised reference materials meeting 99% purity specifications can ensure method accuracy, precision, and regulatory acceptance. Published HPLC-MS/MS methods for simultaneous determination of 5-MAPB and related benzofurans in blood, body fluids, hair, and tissues explicitly depend on having pure 5-MAPB reference material for calibration and retention-time verification.pmc.ncbi.nlm.nih+3

Principal Laboratory Applications and Research Methodologies

Analytical Toxicology & Forensic Chemistry: 5-MAPB serves as a certified reference material (CRM) for mass spectral library development in LC-MS/MS and GC-MS platforms used in forensic toxicology, workplace drug testing, and post-mortem analysis. The compound’s well-characterised fragmentation pattern under electron ionisation (EI) and electrospray ionisation (ESI) conditions enables definitive identification in complex biological matrices, supporting method validation for confirmatory testing protocols targeting N-methylbenzofuran entactogens. European and USA forensic laboratories utilise 5-MAPB reference standards for proficiency testing schemes and NPS monitoring programmes, ensuring analytical competency in detecting novel psychoactive substances within the benzofuran SNDRA class. Validated MRM transitions for 5-MAPB detection include the molecular ion [M+H]⁺ at m/z 190.1226 (exact mass for C₁₂H₁₆NO⁺) and characteristic benzofuran and methylaminopropyl fragments, with molecular formula C₁₂H₁₅NO and molecular weight 189.25 g/mol enabling precise mass detection in high-resolution mass spectrometry (HRMS) workflows. Detection limits in validated methods typically reach 5–50 ng/mL in urine, blood, and oral fluid matrices. 5-MAPB and related benzofurans including 5-APB, 6-APB, and 6-MAPB have been detected in forensic casework and are subject to regulatory control in multiple jurisdictions.pmc.ncbi.nlm.nih+4

Monoamine Transporter Pharmacology: Within strictly controlled in vitro modelling frameworks, 5-MAPB reference material supports transporter-binding affinity studies at serotonin (SERT), norepinephrine (NET), and dopamine (DAT) transporters, as well as functional monoamine release assays using transfected cell lines expressing specific transporter subtypes. These investigations, conducted exclusively in accredited laboratory environments by qualified personnel, generate critical data on transporter binding affinity (Kᵢ values), functional potency (EC₅₀ values), and structure-activity relationships within the benzofuran entactogen class. 5-MAPB is a potent monoamine releasing agent with EC₅₀ values for induction of monoamine release of 64 nM for serotonin, 24 nM for norepinephrine, and 41 nM for dopamine using rat brain synaptosomes, demonstrating a serotonin–norepinephrine–dopamine releasing agent profile similar to MDMA and MDA. It also acts as a partial agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors, with binding affinity data showing 5-MAPB displaces 33% ³H-nisoxetine (NET), 73% ³H-BTCP (DAT), and 75% ³H-citalopram (SERT) at 10µM concentration. The N-methyl substitution on the aminopropyl side chain combined with the 5-benzofuran moiety confers distinct pharmacological properties compared to unsubstituted 5-APB, 6-MAPB, or methylenedioxy-substituted (MDMA, MDA) analogues, making it a valuable reference compound for dissecting N-alkyl effects on monoamine transporter selectivity, biased release, and signal transduction pathways. All such applications must be performed within institutional frameworks (university, CRO, or pharmaceutical R&D) adhering to appropriate ethical and biosafety protocols.pmc.ncbi.nlm.nih+5

Chemical Synthesis & Reaction Monitoring: As a high-purity N-methylbenzofuran, 5-MAPB functions as a reference standard for monitoring synthetic transformations in medicinal chemistry programmes targeting monoamine transporter modulators. The 1-(benzofuran-5-yl)-N-methylpropan-2-amine structure imparts distinct electronic and steric properties compared to N-desmethyl (5-APB), 6-benzofuran (6-MAPB), or methylenedioxy-substituted (MDMA) analogues, making this compound valuable for structure-activity relationship (SAR) studies examining N-alkyl substitution and benzofuran ring position effects on transporter binding affinity, metabolic stability, and cytochrome P450 interactions. Analytical chemists employ 5-MAPB as an internal standard for HPLC quantification of reaction intermediates in the synthesis of related benzofuran entactogens, leveraging its well-resolved chromatographic behaviour and UV absorption characteristics.pmc.ncbi.nlm.nih+3

Method Validation & Calibration: 5-MAPB hydrochloride powder provides a stable, accurately dosed source for constructing calibration curves in quantitative LC-MS/MS assays, with bulk powdered material enabling preparation of multiple stock solution aliquots at defined concentrations (e.g., 1mM in anhydrous methanol, acetonitrile, or aqueous buffers). The powdered form ensures consistent mass delivery across multiple preparations, reducing inter-assay variability in forensic and clinical toxicology laboratories analysing benzofuran entactogen samples. This application is strictly limited to in vitro analytical method development and validation, never extending to human or animal administration. Reference materials for 5-MAPB hydrochloride are supplied as crystalline solids with molecular weight 225.72 g/mol (C₁₂H₁₅NO·HCl) and purity ≥98%.caymanchem+3

Compound Stability, Optimal Storage, and Safe Handling Protocols

5-MAPB hydrochloride, as a substituted benzofuran entactogen, exhibits moderate susceptibility to oxidative degradation, photolytic decomposition, and hydrolytic degradation when exposed to ambient atmospheric conditions, light, and moisture. The benzofuran ring system combined with the secondary amine (N-methyl) moiety confers baseline chemical stability, yet long-term integrity demands strict adherence to prescribed storage protocols.

Short-Term Storage (+4°C): For active laboratory use within 3–6 months, store 5-MAPB powder in its original amber glass vials at +4°C (refrigerated conditions), protected from light and moisture. Ensure vials remain tightly sealed with desiccant packets intact, and ideally under inert atmosphere (nitrogen or argon) to prevent atmospheric moisture and oxygen from inducing degradation. Equilibrate vials to room temperature in a desiccator before opening to minimise condensation formation on the powder surface.

Long-Term Storage (-20°C or -80°C): For extended preservation beyond 6 months, transfer 5-MAPB powder to -20°C (preferably -80°C for multi-year storage) in airtight, desiccated containers shielded from light and, ideally, under inert atmosphere. Under these conditions—sealed, desiccated, -20°C, protected from light, inert atmosphere—powdered 5-MAPB maintains specification compliance for 24–36 months, as evidenced by stability data on analogous benzofuran reference standards. Avoid repeated freeze-thaw cycles by aliquoting powder into single-use vials before freezing.caymanchem+2

Safe Handling Prerequisites: All handling of 5-MAPB powder must occur within a certified chemical fume hood, with personnel wearing appropriate personal protective equipment (PPE): nitrile gloves, safety goggles, and a laboratory coat. The powdered form presents higher aerosolisation risk compared to capsules or solutions; avoid generating dust clouds during weighing or transfer operations. For stock solution preparation, 5-MAPB hydrochloride demonstrates solubility in polar organic solvents including anhydrous methanol, ethanol, acetonitrile, dimethyl sulfoxide (DMSO), and aqueous buffers (pH 4–7) to concentrations of 1–10mM or higher. Prepare solutions fresh or store as frozen aliquots at -20°C to prevent hydrolytic or oxidative degradation. Given the controlled substance status of 5-MAPB and related benzofuran entactogens in many jurisdictions (scheduled as a temporary Class B drug in the UK under the Misuse of Drugs Act 1971, controlled in multiple EU member states under NPS legislation, and subject to analogue act enforcement in the USA), implement additional security protocols to prevent unauthorised access or diversion. 5-MAPB is a controlled substance in multiple jurisdictions and may be subject to regulatory control.uschemshop+3

Technical Specifications and Molecular Attributes

Roid Chem Store: Your Premier EU Vendor for High-Purity Reagents

Roid Chem Store transcends the conventional supplier model, positioning itself as an indispensable partner in USA AND European scientific rigour for analytical chemists, forensic toxicologists, and monoamine transporter pharmacologists. Our hypothetical ISO 9001-certified quality management system underpins every operational facet—from raw material sourcing through final release testing—ensuring consistent adherence to the stringent purity and documentation standards demanded by modern research.

Our dedicated logistics chain guarantees discreet, temperature-controlled shipping across all EU member states and the USA, with expedited delivery options for time-sensitive research programmes. Each shipment is packaged in compliance with international chemical transport regulations, utilising tamper-evident, light-shielded containers with integrated desiccant systems and, for sensitive compounds, inert atmosphere packaging to preserve compound integrity during transit. Given the controlled substance status of 5-MAPB in the UK (temporary Class B), multiple EU member states, and potential analogue act enforcement in the USA, all shipments include appropriate regulatory documentation and are restricted to licensed research facilities with valid institutional approvals (home office licenses, state controlled substance licenses, or EU equivalent).

Beyond logistics, Roid Chem Store distinguishes itself through expert customer support capable of discussing analytical specifications, CoA interpretation, and application-specific guidance for in vitro assay development. Our team comprises analytical chemists and regulatory specialists who understand the nuanced requirements of forensic benzofuran method validation, mass spectral library development, and monoamine transporter pharmacology. When you partner with Roid Chem Store, you gain access not merely to a chemical inventory, but to a comprehensive scientific resource committed to advancing the frontiers of laboratory research.